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      Targeting CA 19-9 with a humanized monoclonal antibody at the time of surgery may decrease recurrence rates for patients undergoing resections for pancreatic cancer, cholangiocarcinoma and metastatic colorectal cancer

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          Abstract

          Operable gastrointestinal cancers continue to pose significant challenges. Radical resections are rarely curative, and chemotherapy is able to reduce tumor recurrence for only a small percentage of patients. Despite the obvious advantages of extirpation of the identifiable tumor(s), the inflammatory milieu that accompanies surgery and the obligate time off cytotoxic agents allows for activation of remote quiescent disseminated tumor cells, leading to metastatic recurrence. We are conducting a study to determine the safety and efficacy of immediate peri-operative MVT-5873, a cytotoxic monoclonal antibody targeting carbohydrate antigen 19-9 (CA 19-9), in patients undergoing resections pancreatic cancer, cholangiocarcinoma or metastatic colorectal cancer to the liver. Eligible patients will receive a single dose of MVT-5873 three days before resection and four post-operative infusions, before beginning standard adjuvant regimens. MVT-5873 is a human IgG1 antibody isolated from a patient following immunization with a sLe a-KLH vaccine. MVT-5873 demonstrated cell surface binding in sLe a positive human tumor lines and has been shown to be potent in complement-dependent cytotoxicity assays and antibody-dependent cell mediated cytotoxicity assays. In patients with metastatic CA 19-9 producing pancreatic adenocarcinoma, MVT-5873 treatment has been shown to decrease serum CA 19-9 levels and prevent tumor progression. The use of perioperative MVT-5873 has the potential to reduce recurrence rates and prolong survival after resection. This trial may open the door for investigation of additional and/or synergistic agents in the immediate peri-operative period and usher in a new paradigm in the management of surgically treated cancers.

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          Author and article information

          Journal
          J Gastrointest Oncol
          J Gastrointest Oncol
          JGO
          Journal of Gastrointestinal Oncology
          AME Publishing Company
          2078-6891
          2219-679X
          April 2020
          April 2020
          : 11
          : 2
          : 231-235
          Affiliations
          [1]Surgical Oncology Program, Center for Cancer Research, National Cancer Institute , Bethesda, MD, USA
          Author notes
          Correspondence to: Jonathan M. Hernandez, MD. 10 Center Drive, Rm 4-3742, Bethesda, MD 20892, USA. Email: jonathan.hernandez@ 123456nih.gov .
          Article
          PMC7212097 PMC7212097 7212097 jgo-11-02-231
          10.21037/jgo.2020.02.01
          7212097
          32399263
          751e2a0a-4974-45a2-9cf5-de61f03dc6d5
          2020 Journal of Gastrointestinal Oncology. All rights reserved.
          History
          : 16 October 2019
          : 17 December 2019
          Categories
          Short Communication

          adjuvant therapy,pancreatic cancer,carbohydrate antigen 19-9 (CA 19-9),liver metastasis,cholangiocarcinoma

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