4
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1.

      Science (New York, N.Y.)

      Adrenal Glands, physiology, Adrenocorticotropic Hormone, secretion, Animals, Axonal Transport, drug effects, Colchicine, pharmacology, Corticotropin-Releasing Hormone, immunology, Fluorescent Antibody Technique, Hypothalamus, metabolism, Immune Sera, Interleukin-1, Male, Median Eminence, Neurons, Pituitary Gland, Anterior, Rats, Rats, Inbred Strains

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Intraperitoneal administration of human recombinant interleukin-1 (IL-1) to rats can increase blood levels of corticosterone and adrenocorticotropic hormone (ACTH). The route by which IL-1 affects pituitary-adrenal activity is unknown. That the IL-1-induced pituitary-adrenal activation involves an increased secretion of corticotropin-releasing factor (CRF) is indicated by three lines of evidence. First, immunoneutralization of CRF markedly attenuated the IL-1-induced increase of ACTH blood levels. Second, after blockade of fast axonal transport in hypothalamic neurons by colchicine, IL-1 administration decreased the CRF immunostaining in the median eminence, indicating an enhanced release of CRF in response to IL-1. Third, IL-1 did not stimulate ACTH release from primary cultures of anterior pituitary cells. These data further support the notion of the existence of an immunoregulatory feedback circuit between the immune system and the brain.

          Related collections

          Author and article information

          Journal
          2443979

          Comments

          Comment on this article