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      Iron homeostasis in host defence and inflammation.

      1 , 2
      Nature reviews. Immunology

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          Abstract

          Iron is an essential trace element for multicellular organisms and nearly all microorganisms. Although iron is abundant in the environment, common forms of iron are minimally soluble and therefore poorly accessible to biological organisms. Microorganisms entering a mammalian host face multiple mechanisms that further restrict their ability to obtain iron and thereby limit their pathogenicity. Iron levels also modulate host defence, as iron content in macrophages regulates their cytokine production. Here, we review recent advances that highlight the role of systemic and cellular iron-regulating mechanisms in protecting hosts from infection, emphasizing aspects that are applicable to human health and disease.

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          Author and article information

          Journal
          Nat. Rev. Immunol.
          Nature reviews. Immunology
          1474-1741
          1474-1733
          Aug 2015
          : 15
          : 8
          Affiliations
          [1 ] 1] Department of Medicine, David Geffen School of Medicine at University of California. [2] Department of Pathology, David Geffen School of Medicine at University of California, Los Angeles, California 90095-1690, USA.
          [2 ] Department of Medicine, David Geffen School of Medicine at University of California.
          Article
          nri3863 NIHMS766726
          10.1038/nri3863
          26160612
          752da2f3-508f-4d39-b40b-7ad9143b79b4
          History

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