SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model

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Abstract

The gut-brain axis is a bidirectional communication network functionally linking the gut and the central nervous system (CNS). Based on this, the rational manipulation of intestinal microbiota represents a novel attractive therapeutic strategy for the treatment of CNS-associated disorders. In this study, we explored the properties of a probiotic formulation (namely SLAB51) in counteracting brain oxidative damages associated with Alzheimer’s disease (AD). Specifically, transgenic AD mice (3xTg-AD) were treated with SLAB51 and the effects on protein oxidation, neuronal antioxidant defence and repair systems were monitored, with the particular focus on the role of SIRT1-related pathways. We demonstrated that SLAB51 markedly reduced oxidative stress in AD mice brain by activating SIRT1-dependent mechanisms, thus representing a promising therapeutic adjuvant in AD treatment.

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Author and article information

Contributors

Laura Bonfili:

ORCID: http://orcid.org/0000-0002-9542-4310

+390737403247 , laura.bonfili@unicam.it

Journal

Journal ID (nlm-ta): Mol Neurobiol

Journal ID (iso-abbrev): Mol. Neurobiol

Title: Molecular Neurobiology

Publisher: Springer US (New York )

ISSN (Print): 0893-7648

ISSN (Electronic): 1559-1182

Publication date (Electronic): 28 February 2018

Publication date PMC-release: 28 February 2018

Publication date (Print): 2018

Volume: 55

Issue: 10

Pages: 7987-8000

Affiliations

ISNI 0000 0000 9745 6549, GRID grid.5602.1, School of Biosciences and Veterinary Medicine, , University of Camerino, ; Via Gentile III da Varano, 62032 Camerino, MC Italy

Author information

Laura Bonfili http://orcid.org/0000-0002-9542-4310

Article

Publisher ID: 973

DOI: 10.1007/s12035-018-0973-4

PMC ID: 6132798

PubMed ID: 29492848

SO-VID: 753c5591-fe4b-40fa-b75b-3090641819c7

License:

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

History

Date received : 30 October 2017

Date accepted : 19 February 2018

Custom metadata

ScienceOpen disciplines: Neurosciences

Keywords: alzheimer’s disease,oxidation,sirt1,probiotics

Data availability:

ScienceOpen disciplines: Neurosciences

Keywords: alzheimer’s disease, oxidation, sirt1, probiotics

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