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      Hypothalamic-Hypophysial Control of Adrenal Cortical Function in Birds

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          Abstract

          The hypothalamic-hypophysial control of basal adrenal cortical function was investigated in three avian species, by means of adenohypophysectomy (HE) and pituitary autografting (AG). HE led to a marked decrease of the plasma corticosterone content: (36 to 43 % of controls in ducks, 54% in pigeons, 46% in quail), and of adrenal corticosterone (16 % in ducks and pigeons, 30 % in quail), while the adrenal aldosterone content remained unaltered. The biological half-life (T½) of <sup>3</sup>H-corticosterone showed a twofold increase, and the metabolic clearance rate (MCR) of the hormone was reduced to 60 % of the control values, in the duck. These results are discussed in the light of a possible extra-hypophysial adrenocorticotropic control. Provided the post-operative time lapse was sufficient to offer the grafted ectopic pituitary the possibility of functional resumption, the plasma corticosterone level was maintained at 80 % of the control values in ducks, 77 % in pigeons, and 90 % in quail; the T½and MCR of <sup>3</sup>H-corticosterone were also found to be restored. However, the adrenal corticosterone content was low (30 % of the control values in ducks and pigeons, 75% in quail); the adrenal aldosterone level was normal. The relative importance of CRF is discussed.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1971
          1971
          19 March 2008
          : 7
          : 5-6
          : 308-321
          Affiliations
          Laboratoire de Neuroendocrinologie – E.R.A. 85 du C.N.R.S., Département de Physiologie Animale, Faculté des Sciences, Université de Montpellier, Montpellier
          Article
          121979 Neuroendocrinology 1971;7:308–321
          10.1159/000121979
          5089011
          © 1971 S. Karger AG, Basel

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          Pages: 14
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