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      Effects of Epinephrine on Retinal and Choroidal Blood Flow through Different Routes of Drug Administration

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          Epinephrine (1, 3 and 10 μg/kg) was found to increase retinal and choroidal blood flow (22, 49 and 67%) when it was administered intravenously. The increase in retinal and choroidal blood flow coincided well with the increase in systemic blood pressure (44, 65 and 96%, respectively). When epinephrine (2%) was instilled to the eyes topically the retinal and choroidal blood flow decreased (15%) while systemic blood pressure remained unchanged. It is suggested that the decrease in retinal and choroidal blood flow by topical epinephrine could be the cause of epinephrine maculopathy reported previously. L-Timolol (0.25%, topically) did not affect retinal and choroidal blood flow significantly.

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          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          10 December 2009
          : 20
          : 5
          : 293-297
          Institute of Ocular Pharmacology, Department of Medical Pharmacology and Toxicology, Texas A & M University College of Medicine; Center for Biotechnology, Baylor College of Medicine, The Woodlands, Tex., USA
          266728 Ophthalmic Res 1988;20:293–297
          © 1988 S. Karger AG, Basel

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          Pages: 5
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