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      Functions of bromodomain-containing proteins and their roles in homeostasis and cancer

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      Nature Reviews Molecular Cell Biology
      Springer Nature

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          Abstract

          Bromodomains (BRDs) are domains found in diverse proteins that recognize acetylated Lys residues, primarily on histones. Hence, BRD-containing proteins serve as readers of protein acetylation and engage in the regulation of gene expression. Recent studies have provided new insights into the physiological roles of BRD-containing proteins and their deregulation in cancer.

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          Author and article information

          Journal
          Nature Reviews Molecular Cell Biology
          Nat Rev Mol Cell Biol
          Springer Nature
          1471-0072
          1471-0080
          January 5 2017
          January 5 2017
          :
          :
          Article
          10.1038/nrm.2016.143
          28053347
          75577965-6124-47e8-9476-6dd0b68c4f85
          © 2017
          History

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