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      Two randomized trials of linaclotide for chronic constipation.

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          Abstract

          Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase C receptor. In two trials, we aimed to determine the efficacy and safety of linaclotide in patients with chronic constipation.

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          Author and article information

          Journal
          N Engl J Med
          The New England journal of medicine
          Massachusetts Medical Society
          1533-4406
          0028-4793
          Aug 11 2011
          : 365
          : 6
          Affiliations
          [1 ] Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA.
          Article
          10.1056/NEJMoa1010863
          21830967
          755b0055-175c-489b-9132-d5878a54cfbd
          History

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