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Computational analysis identifies human adenovirus type 55 as a re-emergent acute respiratory disease pathogen.

Author(s): Hannah M Jones, Donald Seto, Jason Seto, John Walsh, James Chodosh, Wenbo Xu

Publication date: 2010-02-28

Journal: Journal of Clinical Microbiology

Keywords: Adenovirus Infections, Human, epidemiology, virology, Adenoviruses, Human, genetics, isolation & purification, Capsid Proteins, China, Communicable Diseases, Emerging, Computational Biology, DNA, Viral, Disease Outbreaks, Evolution, Molecular, Humans, Recombination, Genetic, Respiratory Tract Infections

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Abstract

Novel human adenoviruses (HAdVs) arise from genome recombination. Analysis of HAdV type 55 from an outbreak in China shows a hexon recombination between HAdV-B11 and HAdV-B14, resulting in a genome that is 97.4% HAdV-B14. Sporadic appearances as a re-emergent pathogen and misidentification as "HAdV-B11a" are due to this partial hexon.

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PubMed ID:: 20042633

PMC ID:: 2832463

DOI:: 10.1128/JCM.01694-09

ScienceOpen disciplines: Chemistry

Keywords: Adenovirus Infections, Human,epidemiology,virology,Adenoviruses, Human,genetics,isolation & purification,Capsid Proteins,China,Communicable Diseases, Emerging,Computational Biology,DNA, Viral,Disease Outbreaks,Evolution, Molecular,Humans,Recombination, Genetic,Respiratory Tract Infections

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ScienceOpen disciplines: Chemistry

Computational analysis identifies human adenovirus type 55 as a re-emergent acute respiratory disease pathogen.

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