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      Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing.

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          Abstract

          Warfarin is a widely used anticoagulant with a narrow therapeutic index and large interpatient variability in the dose required to achieve target anticoagulation. Common genetic variants in the cytochrome P450-2C9 (CYP2C9) and vitamin K-epoxide reductase complex (VKORC1) enzymes, in addition to known nongenetic factors, account for ~50% of warfarin dose variability. The purpose of this article is to assist in the interpretation and use of CYP2C9 and VKORC1 genotype data for estimating therapeutic warfarin dose to achieve an INR of 2-3, should genotype results be available to the clinician. The Clinical Pharmacogenetics Implementation Consortium (CPIC) of the National Institutes of Health Pharmacogenomics Research Network develops peer-reviewed gene-drug guidelines that are published and updated periodically on http://www.pharmgkb.org based on new developments in the field.(1).

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          Author and article information

          Journal
          Clin Pharmacol Ther
          Clinical pharmacology and therapeutics
          Springer Science and Business Media LLC
          1532-6535
          0009-9236
          Oct 2011
          : 90
          : 4
          Affiliations
          [1 ] Department of Pharmacotherapy and Translational Research, College of Pharmacy, and Center for Pharmacogenomics, University of Florida, Gainesville, Florida, USA. Johnson@cop.ufl.edu
          Article
          clpt2011185 NIHMS327024
          10.1038/clpt.2011.185
          3187550
          21900891
          755b68ff-9faa-4859-925a-bfe8f9f3bfce
          History

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