Blog
About

27
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Soft Sweeps : Molecular Population Genetics of Adaptation From Standing Genetic Variation

      ,

      Genetics

      Genetics Society of America

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A population can adapt to a rapid environmental change or habitat expansion in two ways. It may adapt either through new beneficial mutations that subsequently sweep through the population or by using alleles from the standing genetic variation. We use diffusion theory to calculate the probabilities for selective adaptations and find a large increase in the fixation probability for weak substitutions, if alleles originate from the standing genetic variation. We then determine the parameter regions where each scenario-standing variation vs. new mutations-is more likely. Adaptations from the standing genetic variation are favored if either the selective advantage is weak or the selection coefficient and the mutation rate are both high. Finally, we analyze the probability of "soft sweeps," where multiple copies of the selected allele contribute to a substitution, and discuss the consequences for the footprint of selection on linked neutral variation. We find that soft sweeps with weaker selective footprints are likely under both scenarios if the mutation rate and/or the selection coefficient is high.

          Related collections

          Most cited references 9

          • Record: found
          • Abstract: not found
          • Article: not found

          The Measurement of Selection on Correlated Characters

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            The hitch-hiking effect of a favourable gene

              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              A Mathematical Theory of Natural and Artificial Selection, Part V: Selection and Mutation

               J B S HALDANE (1927)
                Bookmark

                Author and article information

                Journal
                Genetics
                Genetics
                Genetics Society of America
                0016-6731
                1943-2631
                May 06 2005
                April 2005
                April 2005
                February 16 2005
                : 169
                : 4
                : 2335-2352
                Article
                10.1534/genetics.104.036947
                1449620
                15716498
                © 2005

                Comments

                Comment on this article