6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Sorbicillinoids from Fungi and Their Bioactivities

      review-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Sorbicillinoids are important hexaketide metabolites derived from fungi. They have a variety of biological activities including cytotoxic, antioxidant, antiviral and antimicrobial activity. The unique structural features of the sorbicillinoids make them attractive candidates for developing new pharmaceutical and agrochemical agents. About 90 sorbicillinoids have been reported in the past few decades. This mini-review aims to briefly summarize their occurrence, structures, and biological activities.

          Related collections

          Most cited references69

          • Record: found
          • Abstract: found
          • Article: not found

          Radical medicine: treating ageing to cure disease.

          The incidence of many diseases rises sharply with age. Although clearly separable, ageing and certain age-related diseases might share common mechanisms. Cellular metabolism and subsequent generation of reactive oxygen species might contribute both to the rate at which we age and to our susceptibility to numerous chronic diseases, therefore therapies that directly target the ageing process might provide new ways to treat human diseases.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            The sorbicillinoid family of natural products: isolation, biosynthesis, and synthetic studies.

            The sorbicillinoids are a family of hexaketide metabolites that have been isolated from a variety of fungal sources, collected from both marine and terrestrial sources. Since 1948, the family has grown in size to include over 50 members, many of which have complex, highly oxygenated, bicyclic and tricyclic frameworks. In conjunction with their biological activity, the structural complexity of these structures has inspired several synthetic campaigns and has also led to controversy surrounding the biosynthetic pathway responsible for the natural production of these compounds. Through this review, we aim to give a historical perspective to each of these areas and hope to inspire new avenues of research for addressing the knowledge gaps that still exist.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Sorbicatechols A and B, antiviral sorbicillinoids from the marine-derived fungus Penicillium chrysogenum PJX-17.

              Two novel sorbicillinoids combining a bicyclo[2.2.2]octane with a 2-methoxyphenol moiety, named sorbicatechols A (1) and B (2), were isolated from the culture of the marine sediment-derived fungus Penicillium chrysogenum PJX-17, together with the known protocatechuic acid methyl ester and caffeic acid methyl ester (3). Their structures, including absolute configurations, were assigned by analysis of NMR, MS data, and TDDFT ECD calculations. Compounds 1 and 2 exhibited activities against influenza virus A (H1N1), with IC50 values of 85 and 113 μ M, respectively.
                Bookmark

                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Molecules
                Molecules
                molecules
                Molecules
                MDPI
                1420-3049
                01 June 2016
                June 2016
                : 21
                : 6
                Affiliations
                Key Laboratory of Plant Pathology, Ministry of Agriculture/Department of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, China; mengjiajiax@ 123456163.com (J.M.); wangxiaohan99@ 123456126.com (X.W.); cauxudan@ 123456163.com (D.X.); xiaoxiaofu@ 123456cau.edu.cn (X.F.); zhangxuping5@ 123456163.com (X.Z.); dwlai@ 123456cau.edu.cn (D.L.)
                Author notes
                [* ] Correspondence: lgzhou@ 123456cau.edu.cn (L.Z.); zhanggzh@ 123456cau.edu.cn (G.Z.); Tel.: +86-10-6273-1199 (L.Z.); +86-10-6273-3259 (G.Z.)
                Article
                molecules-21-00715
                10.3390/molecules21060715
                6273499
                27258245
                756d9763-da41-4e54-842c-f49f30c3d442
                © 2016 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license ( http://creativecommons.org/licenses/by/4.0/).

                Categories
                Review

                sorbicillin,sorbicillinoids,bisorbicillinoids,trisorbicillinoids,vertinoids,fungi,occurrence,biological activities

                Comments

                Comment on this article