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      Sorbicillinoids from Fungi and Their Bioactivities

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          Abstract

          Sorbicillinoids are important hexaketide metabolites derived from fungi. They have a variety of biological activities including cytotoxic, antioxidant, antiviral and antimicrobial activity. The unique structural features of the sorbicillinoids make them attractive candidates for developing new pharmaceutical and agrochemical agents. About 90 sorbicillinoids have been reported in the past few decades. This mini-review aims to briefly summarize their occurrence, structures, and biological activities.

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          The sorbicillinoid family of natural products: isolation, biosynthesis, and synthetic studies.

          Andrew M Harned, Kelly Volp (2011)
          The sorbicillinoids are a family of hexaketide metabolites that have been isolated from a variety of fungal sources, collected from both marine and terrestrial sources. Since 1948, the family has grown in size to include over 50 members, many of which have complex, highly oxygenated, bicyclic and tricyclic frameworks. In conjunction with their biological activity, the structural complexity of these structures has inspired several synthetic campaigns and has also led to controversy surrounding the biosynthetic pathway responsible for the natural production of these compounds. Through this review, we aim to give a historical perspective to each of these areas and hope to inspire new avenues of research for addressing the knowledge gaps that still exist.
          Article 0 comments Cited 49 times – based on 0 reviews     Review now
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            Radical medicine: treating ageing to cure disease.

            Toren Finkel (2005)
            The incidence of many diseases rises sharply with age. Although clearly separable, ageing and certain age-related diseases might share common mechanisms. Cellular metabolism and subsequent generation of reactive oxygen species might contribute both to the rate at which we age and to our susceptibility to numerous chronic diseases, therefore therapies that directly target the ageing process might provide new ways to treat human diseases.
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              Sorbicatechols A and B, antiviral sorbicillinoids from the marine-derived fungus Penicillium chrysogenum PJX-17.

              Jixing Peng, Xiaomin Zhang, Lin Du … (2014)
              Two novel sorbicillinoids combining a bicyclo[2.2.2]octane with a 2-methoxyphenol moiety, named sorbicatechols A (1) and B (2), were isolated from the culture of the marine sediment-derived fungus Penicillium chrysogenum PJX-17, together with the known protocatechuic acid methyl ester and caffeic acid methyl ester (3). Their structures, including absolute configurations, were assigned by analysis of NMR, MS data, and TDDFT ECD calculations. Compounds 1 and 2 exhibited activities against influenza virus A (H1N1), with IC50 values of 85 and 113 μ M, respectively.
              Article 0 comments Cited 32 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Kira J. Weissman: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Molecules
                Journal ID (iso-abbrev): Molecules
                Journal ID (publisher-id): molecules
                Title: Molecules
                Publisher: MDPI
                ISSN (Electronic): 1420-3049
                Publication date (Electronic): 01 June 2016
                Publication date Collection: June 2016
                Volume: 21
                Issue: 6
                Electronic Location Identifier: 715
                Affiliations
                Key Laboratory of Plant Pathology, Ministry of Agriculture/Department of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, China; mengjiajiax@ 123456163.com (J.M.); wangxiaohan99@ 123456126.com (X.W.); cauxudan@ 123456163.com (D.X.); xiaoxiaofu@ 123456cau.edu.cn (X.F.); zhangxuping5@ 123456163.com (X.Z.); dwlai@ 123456cau.edu.cn (D.L.)
                Author notes
                [* ] Correspondence: lgzhou@ 123456cau.edu.cn (L.Z.); zhanggzh@ 123456cau.edu.cn (G.Z.); Tel.: +86-10-6273-1199 (L.Z.); +86-10-6273-3259 (G.Z.)
                Article
                Publisher ID: molecules-21-00715
                DOI: 10.3390/molecules21060715
                PMC ID: 6273499
                PubMed ID: 27258245
                SO-VID: 756d9763-da41-4e54-842c-f49f30c3d442
                Copyright © © 2016 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 06 April 2016
                Date accepted : 27 May 2016
                Categories
                Subject: Review

                Keywords: sorbicillin,sorbicillinoids,bisorbicillinoids,trisorbicillinoids,vertinoids,fungi,occurrence,biological activities
                Data availability:
                Keywords: sorbicillin, sorbicillinoids, bisorbicillinoids, trisorbicillinoids, vertinoids, fungi, occurrence, biological activities

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