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      Microparticles initiate decompression-induced neutrophil activation and subsequent vascular injuries.

      Journal of Applied Physiology
      Animals, Cell-Derived Microparticles, metabolism, Decompression, methods, Decompression Sickness, immunology, pathology, Mice, Mice, Knockout, Neutrophil Activation, Vascular Diseases

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          Abstract

          Progressive elevations in circulating annexin V-coated microparticles (MPs) derived from leukocytes, erythrocytes, platelets, and endothelial cells are found in mice subjected to increasing decompression stresses. Individual MPs exhibit surface markers from multiple cells. MPs expressing platelet surface markers, in particular, interact with circulating neutrophils, causing them to degranulate and leading to further MP production. MPs can be lysed by incubation with polyethylene glycol (PEG) telomere B surfactant, and the number of circulating MPs is reduced by infusion of mice with PEG or antibody to annexin V. Myeloperoxidase deposition and neutrophil sequestration in tissues occur in response to decompression, and the pattern differs among brain, omentum, psoas, and leg skeletal muscle. Both MP abatement strategies reduce decompression-induced intravascular neutrophil activation, neutrophil sequestration, and tissue injury documented as elevations of vascular permeability and activated caspase-3. We conclude that MPs generated by decompression stresses precipitate neutrophil activation and vascular damage.

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          Author and article information

          Journal
          20966192
          10.1152/japplphysiol.00811.2010

          Chemistry
          Animals,Cell-Derived Microparticles,metabolism,Decompression,methods,Decompression Sickness,immunology,pathology,Mice,Mice, Knockout,Neutrophil Activation,Vascular Diseases

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