Pirfenidone, nintedanib and N-acetylcysteine for the treatment of idiopathic pulmonary fibrosis: A systematic review and meta-analysis.

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Abstract

The prevalence of idiopathic pulmonary fibrosis (IPF) is increasing every year. Pirfenidone and nintedanib were approved for treatment of IPF in 2014, but they received only a conditional recommendation for use and, thus, to date no drugs are strongly recommended for IPF. The aim of this study was to assess the effectiveness and safety of the currently approved drugs for IPF and N-acetylcysteine (NAC), the most debated drug in the last update of guidelines for IPF treatment.

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Journal

Journal ID (iso-abbrev): Pulm Pharmacol Ther

Title: Pulmonary pharmacology & therapeutics

Publisher: Elsevier BV

ISSN (Electronic): 1522-9629

ISSN (Print): 1094-5539

Publication date (Electronic): Oct 2016

Volume: 40

Affiliations

[1 ] University of Rome Tor Vergata, Department of Systems Medicine, Unit of Respiratory Clinical Pharmacology, Rome, Italy; University of Rome Tor Vergata, Department of Systems Medicine, Chair of Respiratory Medicine, Rome, Italy.

[2 ] University of Rome Tor Vergata, Department of Systems Medicine, Unit of Respiratory Clinical Pharmacology, Rome, Italy. Electronic address: luigino.calzetta@uniroma2.it.

[3 ] University of Rome Tor Vergata, Department of Systems Medicine, Chair of Respiratory Medicine, Rome, Italy.

[4 ] Second University of Naples, Department of Experimental Medicine, Unit of Pharmacology, Naples, Italy.

Article

Publisher Item ID: S1094-5539(16)30061-X

DOI: 10.1016/j.pupt.2016.07.009

PubMed ID: 27481628

SO-VID: 757c0d62-b0f5-4592-9000-619f8b31c48f

History

Keywords: IPF,Therapy,Meta-analysis

Data availability:

Keywords: IPF, Therapy, Meta-analysis

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