ScienceOpen:
research and publishing network
For Publishers
Discovery
Metadata
Peer review
Hosting
Publishing
For Researchers
Join
Publish
Review
Collect
My ScienceOpen
Sign in
Register
Dashboard
Blog
About
Search
Advanced search
My ScienceOpen
Sign in
Register
Dashboard
Search
Search
Advanced search
For Publishers
Discovery
Metadata
Peer review
Hosting
Publishing
For Researchers
Join
Publish
Review
Collect
Blog
About
111
views
0
references
Top references
cited by
154
Cite as...
0 reviews
Review
0
comments
Comment
0
recommends
+1
Recommend
0
collections
Add to
0
shares
Share
Twitter
Sina Weibo
Facebook
Email
1,768
similar
All similar
Record
: found
Abstract
: not found
Article
: not found
Poor-quality antimalarial drugs in southeast Asia and sub-Saharan Africa
Author(s):
Gaurvika ML Nayyar
,
Joel G Breman
,
Paul N Newton
,
James Herrington
Publication date
Created:
June 2012
Publication date
(Print):
June 2012
Journal:
The Lancet Infectious Diseases
Publisher:
Elsevier BV
Read this article at
ScienceOpen
Publisher
PubMed
Review
Review article
Invite someone to review
Bookmark
Cite as...
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Poor-quality antimalarial drugs lead to drug resistance and inadequate treatment, which pose an urgent threat to vulnerable populations and jeopardise progress and investments in combating malaria. Emergence of artemisinin resistance or tolerance in Plasmodium falciparum on the Thailand-Cambodia border makes protection of the effectiveness of the drug supply imperative. We reviewed published and unpublished studies reporting chemical analyses and assessments of packaging of antimalarial drugs. Of 1437 samples of drugs in five classes from seven countries in southeast Asia, 497 (35%) failed chemical analysis, 423 (46%) of 919 failed packaging analysis, and 450 (36%) of 1260 were classified as falsified. In 21 surveys of drugs from six classes from 21 countries in sub-Saharan Africa, 796 (35%) of 2297 failed chemical analysis, 28 (36%) of 77 failed packaging analysis, and 79 (20%) of 389 were classified as falsified. Data were insufficient to identify the frequency of substandard (products resulting from poor manufacturing) antimalarial drugs, and packaging analysis data were scarce. Concurrent interventions and a multifaceted approach are needed to define and eliminate criminal production, distribution, and poor manufacturing of antimalarial drugs. Empowering of national medicine regulatory authorities to protect the global drug supply is more important than ever. Copyright © 2012 Elsevier Ltd. All rights reserved.
Related collections
Asian Journal of Quality of Life (AjQoL)
Author and article information
Journal
Title:
The Lancet Infectious Diseases
Abbreviated Title:
The Lancet Infectious Diseases
Publisher:
Elsevier BV
ISSN (Print):
14733099
Publication date Created:
June 2012
Publication date (Print):
June 2012
Volume
: 12
Issue
: 6
Pages
: 488-496
Article
DOI:
10.1016/S1473-3099(12)70064-6
PubMed ID:
22632187
SO-VID:
758aec54-1333-4651-99a3-52b5b43da7dc
Copyright ©
© 2012
License:
https://www.elsevier.com/tdm/userlicense/1.0/
History
Data availability:
Comments
Comment on this article
Sign in to comment
scite_
Similar content
1,768
Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098.
Authors:
Detlef Geffken
,
Uwe Kaula
,
Daniela K. Schlüter
…
Medicinal plants from the Yanesha (Perú): Evaluation of the leishmanicidad and antimalarial activity of selected extract
Authors:
C Valadeau
,
A Pabón
,
E Deharo
…
Apicidins: Novel cyclic tetrapeptides as coccidiostats and antimalarial agents from Fusarium pallidoroseum
Authors:
Sheo Singh
,
Deborah Zink
,
Jon Polishook
…
See all similar
Cited by
149
Physical unclonable functions generated through chemical methods for anti-counterfeiting
Authors:
Riikka Arppe
,
Thomas Sørensen
Malaria eradication within a generation: ambitious, achievable, and necessary
Authors:
Richard G A Feachem
,
Ingrid Chen
,
Omar Akbari
…
Prevalence and Estimated Economic Burden of Substandard and Falsified Medicines in Low- and Middle-Income Countries
Authors:
Sachiko Ozawa
,
Daniel Evans
,
Sophia Bessias
…
See all cited by
Version 1
- Current
Version 1
Version 1