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      Correlations between Indices of Heart Rate Variability in Healthy Children and Children with Congenital Heart Disease

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          Heart rate variability, as determined from 24-hour Holter recordings, represents a noninvasive parameter for studying the autonomic control of the heart. It decreases with certain disease states characterized by autonomic dysfunction such as congestive heart failure. No study in healthy or cardiac children has been performed to determine the correlations between and within time and frequency domain indices of heart rate variability. We examined five time domain (SDNN, SDNNi, SDANNi, rMSSD and pNN50) and five frequency domain measures (ULF, VLF, LF, HF and balance LF/HF) in 200 healthy children and 200 children with congenital heart disease, aged 3 days to 14 years. All measures were significantly correlated with each other. However, the strength of correlation varied greatly. Our data show that variables strongly dependent on vagal tone (rMSSD, pNN50 and HF) were highly correlated (r value > 0.90), as well as SDNN and SDANNi. We conclude that certain time and frequency domain indices correlate so strongly with each other that they can act as surrogates for each other.

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          Normal Ranges of Heart Rate Variability During Infancy and Childhood

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            Heart Rate Behavior in Children with Atrial Septal Defect

            The aim of this study was to assess heart rate variability, a noninvasive parameter for studying the neurohumoral control of heart rate, in children with atrial septal defect. We examined five time-domain and three frequency-domain indices of heart rate variability determined from 24-hour Holter recordings in 20 children, aged 3–14 years, with secundum atrial septal defect who were about to undergo operation. The measures were compared to normal ranges and to the hemodynamic data of the preoperative cardiac catheterization. Most indices of heart rate variability were moderately depressed in children with atrial septal defect. Our data revealed negative correlations between indices and the mean right atrial pressure and the enddiastolic right ventricular pressure, respectively. The study demonstrates the importance of the right ventricular filling pressures for the autonomic control of the heart in children with atrial septal defect.

              Author and article information

              S. Karger AG
              August 1999
              06 August 1999
              : 91
              : 2
              : 109-113
              aDivision of Pediatric Cardiology, CHR Citadelle, University of Liège, Belgium, bDepartment of Pediatric Cardiology, Klinikum der RWTH Aachen, Germany
              6889 Cardiology 1999;91:109–113
              © 1999 S. Karger AG, Basel

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              Page count
              Figures: 3, Tables: 2, References: 13, Pages: 5
              Congenital Heart Disease


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