The purpose of this study is to analyze the 18F-FDG PET/CT features of solid renal masses detected in patients with lymphoma and to evaluate the ability of PET/CT to differentiate renal cell carcinoma (RCC) from renal lymphomatous involvement.
Thirty-six patients with solid renal masses on PET/CT performed for staging or follow-up of lymphoma were evaluated retrospectively. The features recorded for each renal mass included the following standardized uptake values (SUVs) on PET/CT: the maximum SUV (SUV max), the mean SUV (SUV mean), the ratio of the SUV max of the tumor to that of the normal kidney cortex, the ratio of the SUV mean of the tumor to that of the normal kidney cortex, the ratio of the SUV max of the tumor to that of the normal liver, and the ratio of the SUV mean of the tumor to that of the normal liver. Renal mass size and margins (well defined vs infiltrative) and the presence of calcifications were evaluated on CT. Renal biopsy results were used as the reference standard. Relationships between imaging parameters and histopathologic findings were assessed.
Of the 36 renal masses evaluated, 22 (61.1%) were RCCs and 14 (38.9%) were renal lymphomas. All SUV metrics were higher for renal lymphomas than for RCCs ( p< 0.0001, for all). All renal lymphomas had an SUV max higher than 5.98 g/mL (median, 10.99 g/mL), whereas all RCCs had an SUV max lower than 5.26 g/mL (median, 2.91 g/mL). No statistically significant differences in mass size or margins were found between RCCs and renal lymphoma.