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      Selective imaging of chronic cardiac rejection using a human antibody specific to the alternatively spliced EDA domain of fibronectin.

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          Abstract

          Chronic cardiac rejection is intimately associated with cardiac allograft vasculopathy and fibrosis, both causing severe complications that cannot be reversed. Thus, there is an urgent need for early diagnosis and for development of therapeutic agents. Chronic rejection is accompanied by the dramatic upregulation of EDA(+) fibronectin (EDA(+) Fn), which is virtually undetectable in the normal healthy adult.

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          Author and article information

          Journal
          J. Heart Lung Transplant.
          The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
          Elsevier BV
          1557-3117
          1053-2498
          Jun 2013
          : 32
          : 6
          Affiliations
          [1 ] Department of Internal Medicine I, University Hospital Jena, Jena, Germany. marcus.franz@med.uni-jena.de
          Article
          S1053-2498(13)01207-2
          10.1016/j.healun.2013.04.003
          23701854
          75a389b0-e0d2-4e1b-bec4-a4424a7f738b
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