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      Catarata induzida por hidroclorotiazida. Relato de caso e revisão da literatura Translated title: Cataract induce d by hydrochlorothiazide


      Arquivos Brasileiros de Oftalmologia

      Conselho Brasileiro de Oftalmologia

      Catarata, hipercalcemia, hidroclorotiazida

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          RESUMO A hidroclorotiazida, um diurético tiazídico largamente utilizado no tratamento da hipertensão arterial sistêmica, pode induzir reações adversas como hipocalemia, hiperglicemia, hiperuricemia e hipercalcemia. É hoje bem estabelecido que o aumento nos níveis séricos de cálcio pode induzir a formação de catarata, porém é raramente descrita na literatura a associação hidroclorotiazida e catarata. Apresentamos um caso morfologicamente típico de catarata por hipercalcemia em uma paciente pré-senil que fazia uso de hidroclorotiazida por cinco anos e presentava níveis elevados de cálcio sérico. Após a suspensão da droga a calcemia voltou ao normal, mas não ocorreram modificações nas características das opacificações cristalinas.

          Translated abstract

          SUMMARY Hydrochlorothiazide, a thiazide diuretic commonly used for the treatment of systemic arterial hypertension, may induce hypokalemia, hyperglycemia, hyperuricemia and hypercalcemia. Nowadays it is known that high seric calcium may lead to cataract formation although the association between hydrochlorothiazide and cataract is rarely described. We are presenting a typical morphologic cataract due to hyupercalcemia in a presenile patient who used hydrochlorothiazide for 5 years and presents elevated seric calcium. After the drug withdraw all the seric calcium returned to normal levels but the tens opacities remain unchanged.

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          Most cited references 13

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          Effect of corticosteroids on cataract formation.

           J Prchal,  H Skalka (1980)
          While the cataractogenic effects of corticosteroids are beyond dispute, disagreement exists concerning effects of total dose, intensity of dose, and duration of administration on cataract formation. We studied 106 adult male patients matched for age, race, and socioeconomic status. We compared posterior subcapsular (PSC) cataract formation among those with (39) and without (67) a history of systemic corticosteroid therapy. Difference in incidence of PSC opacities among patients with and without a history of corticosteroid therapy was statistically significant. However, no statistically significant correlation was found between PSC opacities and total steroid dose, weekly dose (intensity), duration of dose, or age of patient. Our findings agree with some recent literature that suggests the most important factor in steroid-induced PSC cataract formation may be variability in individual susceptibility to side effects of corticosteroids. We suggest abandoning the concept of a "safe" dose.
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            Calcium content and distribution in human cataract.

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              Allopurinol Therapy and Cataractogenesis in Humans


                Author and article information

                Role: ND
                Role: ND
                Arquivos Brasileiros de Oftalmologia
                Arq. Bras. Oftalmol.
                Conselho Brasileiro de Oftalmologia (São Paulo, SP, Brazil )
                September 1990
                : 53
                : 5
                : 229-235
                orgnameHospital de Clínicas de Porto Alegre orgdiv1Setor de Córnea e Doenças Externos Brazil
                orgnameHospital de Clínicas de Porto Alegre Brazil

                This work is licensed under a Creative Commons Attribution 4.0 International License.

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                Figures: 0, Tables: 0, Equations: 0, References: 18, Pages: 7
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                hipercalcemia, Catarata, hidroclorotiazida


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