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      ¿Gel o no gel? he ahí el dilema... tipo de tubo para determinación farmacocinética Translated title: Gel or no gel? that is the dilemma... type of tube for pharmacokinetic determination

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      Revista de la OFIL
      Organización de Farmacéuticos Ibero-Latinoamericanos

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          Where clinical chemistry meets medicinal chemistry. Systematic analysis of physico-chemical properties predicts stability of common used drugs in gel separator serum tubes.

          As LC-MS/MS techniques are becoming more accessible even outside of highly specialized clinical laboratories, pre-analytical issues such as drug stability during specimen storage should be critically evaluated before implementing therapeutic drug monitoring. Our study investigated the influence of physico-chemical properties of different drugs in regard to their interaction with gel separators used in commercial available collection tubes.
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            The right blood collection tube for therapeutic drug monitoring and toxicology screening procedures: Standard tubes, gel or mechanical separator?

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              Influence of separator gel in Sarstedt S-Monovette® serum tubes on various therapeutic drugs, hormones, and proteins.

              A separator or barrier gel is a common component of serum and plasma collection tubes. Despite their advantages, the use of these tubes is not universally accepted, especially for therapeutic drug monitoring (TDM). The aim of this study was to evaluate whether the polyacrylester separator gel in Sarstedt S-Monovette\® tubes influences the concentration of 10 selected parameters (amikacin, vancomycin, valproic acid, acetaminophen, cortisol, free thyroxine, thyroid-stimulating hormone, transferrin, prealbumin and carcinoembryonic antigen) in a clinically significant way.
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                Author and article information

                Journal
                ofil
                Revista de la OFIL
                Rev. OFIL·ILAPHAR
                Organización de Farmacéuticos Ibero-Latinoamericanos (Madrid, Madrid, Spain )
                1131-9429
                1699-714X
                2021
                : 31
                : 2
                : 226
                Affiliations
                [1] Villarreal Castellón orgnameHospital La Plana orgdiv1Servicio de Farmacia España
                Article
                S1699-714X2021000200226 S1699-714X(21)03100200226
                10.4321/s1699-714x2021000200024
                75b62836-48a4-49d4-908c-56c6d955ec66

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 27 January 2021
                : 02 January 2021
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 6, Pages: 1
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                SciELO Spain

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