- Record: found
- Abstract: not found
- Article: not found
Estrogen rapidly potentiates amphetamine-induced striatal dopamine release and rotational behavior during microdialysis
Read this article at
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Ovariectomy (OVX) of female rats results in a decreased behavioral response to stimulation
of the mesostriatal dopamine (DA) system and decreased striatal DA release in vitro.
Estrogen replacement restores both behavioral and neurochemical responsiveness. In
this report, microdialysis in freely moving rats is used to simultaneously study the
behavioral and neurochemical effects of systemic estradiol. OVX rats received a unilateral
6-hydroxy-dopamine lesion of the substantia nigra and then underwent microdialysis
of the intact striatum. Thirty min after a single injection of 5 micrograms estradiol
benzoate, amphetamine-induced rotational behavior and striatal DA release are both
potentiated, relative to the response of oil-treated control animals.