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      Proinflammatory S100A12 can activate human monocytes via Toll-like receptor 4.

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          Abstract

          S100A12 is overexpressed during inflammation and is a marker of inflammatory disease. Furthermore, it has been ascribed to the group of damage-associated molecular pattern molecules that promote inflammation. However, the exact role of human S100A12 during early steps of immune activation and sepsis is only partially described thus far.

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          Author and article information

          Journal
          Am J Respir Crit Care Med
          American journal of respiratory and critical care medicine
          American Thoracic Society
          1535-4970
          1073-449X
          Jun 15 2013
          : 187
          : 12
          Affiliations
          [1 ] Department of Pediatric Rheumatology and Immunology, University Children's Hospital Muenster, Muenster, Germany. dfoell@uni-muenster.de
          Article
          10.1164/rccm.201209-1602OC
          23611140
          75cd88bb-a2a7-4033-a3c1-a7d86d82c870
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