Adiposity and cancer risk: new mechanistic insights from epidemiology.

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Abstract

Excess body adiposity, commonly expressed as body mass index (BMI), is a risk factor for many common adult cancers. Over the past decade, epidemiological data have shown that adiposity-cancer risk associations are specific for gender, site, geographical population, histological subtype and molecular phenotype. The biological mechanisms underpinning these associations are incompletely understood but need to take account of the specificities observed in epidemiology to better inform future prevention strategies.

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Journal

Journal ID (iso-abbrev): Nat. Rev. Cancer

Title: Nature reviews. Cancer

ISSN (Electronic): 1474-1768

ISSN (Print): 1474-175X

Publication date (Electronic): Aug 2015

Volume: 15

Issue: 8

Affiliations

[1 ] Institute of Cancer Sciences, Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.

[2 ] Institute of Social and Preventive Medicine (ISPM), University of Bern, Finkenhubelweg 11, Bern CH-3012, Switzerland.

Article

Publisher Item ID: nrc3967

DOI: 10.1038/nrc3967

PubMed ID: 26205341

SO-VID: 75ce0fc6-30a2-4c88-88a0-b06f2408203b

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