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      Mitofusin 2 Builds a Bridge between ER and Mitochondria

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      Cell

      Elsevier BV

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          Abstract

          Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for mitochondrial fusion, cause the peripheral neuropathy Charcot-Marie-Tooth type 2A. In a recent report in Nature, de Brito and Scorrano (2008) demonstrate a new function of MFN2-tethering the endoplasmic reticulum and mitochondria to control the efficiency of mitochondrial uptake of Ca2+ ions.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          December 2008
          December 2008
          : 135
          : 7
          : 1165-1167
          Article
          10.1016/j.cell.2008.12.005
          19109886
          © 2008

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