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Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for mitochondrial
fusion, cause the peripheral neuropathy Charcot-Marie-Tooth type 2A. In a recent report
in Nature, de Brito and Scorrano (2008) demonstrate a new function of MFN2-tethering
the endoplasmic reticulum and mitochondria to control the efficiency of mitochondrial
uptake of Ca2+ ions.