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      Temporal clustering of exacerbations in chronic obstructive pulmonary disease.

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          Abstract

          Exacerbations are important events in chronic obstructive pulmonary disease. Preventing exacerbations is a key treatment goal. Observational data suggest that after a first exacerbation, patients may be at increased risk of a second exacerbation, but this has not been specifically studied. We hypothesized that exacerbations may cluster together in time, a finding that would have important implications for targeting preventative interventions and the analysis of clinical trial data.

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          Author and article information

          Journal
          Am. J. Respir. Crit. Care Med.
          American journal of respiratory and critical care medicine
          American Thoracic Society
          1535-4970
          1073-449X
          Mar 01 2009
          : 179
          : 5
          Affiliations
          [1 ] Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, London, United Kingdom.
          Article
          200807-1067OC
          10.1164/rccm.200807-1067OC
          19074596
          75eb1626-4ec1-4acd-b45d-7af07de3a5e4
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