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      New strains of bacteria and exacerbations of chronic obstructive pulmonary disease.

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          Abstract

          The role of bacterial pathogens in acute exacerbations of chronic obstructive pulmonary disease is controversial. In older studies, the rates of isolation of bacterial pathogens from sputum were the same during acute exacerbations and during stable disease. However, these studies did not differentiate among strains within a bacterial species and therefore could not detect changes in strains over time. We hypothesized that the acquisition of a new strain of a pathogenic bacterial species is associated with exacerbation of chronic obstructive pulmonary disease.

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          Author and article information

          Journal
          N Engl J Med
          The New England journal of medicine
          Massachusetts Medical Society
          1533-4406
          0028-4793
          Aug 15 2002
          : 347
          : 7
          Affiliations
          [1 ] Division of Pulmonary and Critical Care Medicine, Department of Medicine, State University of New York, Buffalo, NY, USA. ssethi@buffalo.edu
          Article
          347/7/465
          10.1056/NEJMoa012561
          12181400
          760281b8-e8a2-4511-ae9c-30f42a8d5720
          Copyright 2002 Massachusetts Medical Society
          History

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