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      Hypoxanthine, xanthine, and uric acid concentrations in plasma, cerebrospinal fluid, vitreous humor, and urine in piglets subjected to intermittent versus continuous hypoxemia.

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          Abstract

          Infants with sudden infant death syndrome have higher hypoxanthine (Hx) concentrations in their vitreous humor than infants with respiratory distress syndrome and other infant control populations. However, previous research on piglets and pigs applying continuous hypoxemia has not been able to reproduce the concentrations observed in infants with sudden infant death syndrome. To test whether intermittent hypoxemia could, in part, explain this observed difference, Hx, xanthine (X), and uric acid were measured in vitreous humor, urine, plasma, and cerebrospinal fluid in newborn piglets during intermittent hypoxemia (IH) or continuous hypoxemia (CH) of equal degree and duration. Urinary Hx excretion was significantly higher (p < 0.04) in the IH group after 60 min of hypoxemia. The vitreous humor Hx increase was significantly higher in the IH group (from 21.0 +/- 7.8 to 44.1 +/- 25.5 mumol/L, p < 0.01 versus baseline) than in the CH group (from 16.4 +/- 4.2 to 23.2 +/- 7.3 mumol/L, p < 0.05 versus baseline) (p < 0.05 IH versus CH). X increased significantly more (p < 0.05) in vitreous humor in the IH group than in the CH group. No differences between the two groups were found in plasma and cerebrospinal fluid for either Hx, X, or uric acid. We conclude that vitreous humor Hx and X increases more during IH than during CH.

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          Author and article information

          Journal
          Pediatr. Res.
          Pediatric research
          Ovid Technologies (Wolters Kluwer Health)
          0031-3998
          0031-3998
          Dec 1993
          : 34
          : 6
          Affiliations
          [1 ] Department of Pediatric Research, National Hospital, Oslo, Norway.
          Article
          10.1203/00006450-199312000-00013
          8108190
          7602d764-0bc7-4cf7-8852-b584a9097446
          History

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