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      Lymphocyte Subpopulations in Minimal-Change Nephropathy

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          Abstract

          It has been suggested that minimal-change nephropathy (MCN) may be related to a disorder of cell-mediated immunity. Lymphocyte cell-surface markers (E and EAC rosettes) and functional markers (mitogenic response to PHA, Con A and PWM) were examined in 13 patients with MCN and nephrotic syndrome (NS) and in 13 patients with MCN in remission compared to 20 patients with membranous glomerulonephritis (MG) and NS, and 20 normal controls. None of the patients received medication at the time of the study. The response to various mitogens of MCN with NS was significantly reduced, while MCN in remission and MG had mean values of the mitogenic response not significantly different in respect to normal controls. Lymphocyte hyporeactivity in autologous plasma was associated, in approximately 50% of the patients with MCN and NS, to a normal lymphocyte response in homologous plasma and to the presence of an inhibitory effect of MCN plasma on normal lymphocytes. Also, the percentage of E rosettes was reduced, while the percentage of EAC rosettes was increased. The defect of T cells was not related to the degree of the NS. In 7 patients, studied at the onset of NS and afterwards in remission, the functional and numerical lymphocyte deficit disappeared during recovery. There is evidence that MCN is associated with a functional disorder of T cells which may be related to the presence of a humoral inhibiting factor.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1980
          1980
          02 December 2008
          : 25
          : 2
          : 72-76
          Affiliations
          Divisione di Nefrologia e Dialisi e Servizio di Laboratorio, Ospedale Malpighi, Bologna
          Article
          181756 Nephron 1980;25:72–76
          10.1159/000181756
          6965527
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Minimal-change nephropathy, Lymphocytes

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