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      Mechanisms of Distal–Nephron Li + Reabsorption during Dietary K + Restriction in Rats

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          Abstract

          The mechanism by which dietary K<sup>+</sup> restriction induces distal–nephron Li<sup>+</sup> reabsorption was investigated by administration of bendroflumethiazide (BFTZ) or vehicle in conscious Wistar rats. Changes in fractional excretion of Li<sup>+</sup> following administration of amiloride (ΔFE<sub>Li</sub>) were used as an index of distal tubular Li<sup>+</sup> reabsorption. The results revealed an absence of distal tubular Li<sup>+</sup> reabsorption in K<sup>+</sup>–replete rats (ΔFE<sub>Li</sub> = 3.6±2.4%), in contrast to K<sup>+</sup> restriction in which ΔFE<sub>Li</sub> was 24.0±2.7%. The distal tubular Li<sup>+</sup> reabsorption in K<sup>+</sup>–depleted rats was significantly reduced by preadministration of BFTZ (ΔFE<sub>Li</sub> = 9.2±0.9%). The fractions of Li<sup>+</sup> and Na<sup>+</sup> reabsorbed in the amiloride–sensitive segment were different in K<sup>+</sup>–replete rats (9±6 vs. 60±6%), but similar in K<sup>+</sup>–depleted rats (61±5 vs. 73±4%). BFTZ administration to K<sup>+</sup>–depleted rats resulted in a proportional decrease in these fractions, suggesting competition between Na<sup>+</sup> and Li<sup>+</sup> for reabsorption in the distal–nephron segment during K<sup>+</sup> depletion. These results are compatible with the hypothesis that during K<sup>+</sup> depletion the reabsorption of Li<sup>+ </sup>in the distal–nephron segment is competitively inhibited by Na<sup>+</sup>.

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          Inhibition of tubular lithium reabsorption by amiloride in the conscious sodium-restricted rat

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            Author and article information

            Journal
            KBR
            Kidney Blood Press Res
            10.1159/issn.1420-4096
            Kidney and Blood Pressure Research
            S. Karger AG
            1420-4096
            1423-0143
            2000
            2000
            24 March 2000
            : 23
            : 2
            : 83-88
            Affiliations
            aDepartment of Pharmacology, University of Copenhagen, and bDepartment of Biological Psychiatry, Institute for Basic Psychiatric Research, Aarhus University Hospital, Aarhus, Denmark
            Article
            25958 Kidney Blood Press Res 2000;23:83–88
            10.1159/000025958
            10765109
            © 2000 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            Page count
            Figures: 1, Tables: 2, References: 25, Pages: 6
            Product
            Self URI (application/pdf): https://www.karger.com/Article/Pdf/25958
            Categories
            Original Paper

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