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From the Cover: Catalytic Antioxidant Rescue of Inhaled Sulfur Mustard Toxicity

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      Most cited references 59

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      Beyond oxidative stress: an immunologist's guide to reactive oxygen species.

       Carl Nathan,  A Bussel (2013)
      Reactive oxygen species (ROS) react preferentially with certain atoms to modulate functions ranging from cell homeostasis to cell death. Molecular actions include both inhibition and activation of proteins, mutagenesis of DNA and activation of gene transcription. Cellular actions include promotion or suppression of inflammation, immunity and carcinogenesis. ROS help the host to compete against microorganisms and are also involved in intermicrobial competition. ROS chemistry and their pleiotropy make them difficult to localize, to quantify and to manipulate - challenges we must overcome to translate ROS biology into medical advances.
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        Linking oxidative stress to inflammation: Toll-like receptors.

        Injury caused by oxidative stress occurs in many clinical scenarios involving ischemia and reperfusion such as organ transplantation, hemorrhagic shock (HS), myocardial infarction, and cerebral vascular accidents. Activation of the immune system as a result of disturbances in the redox state of cells seems to contribute to tissue and organ damage in these conditions. The link between oxidative stress and inflammatory pathways is poorly understood. Recently, Toll-like receptors (TLRs) have been shown to mediate the inflammatory response seen in experimental ischemia and reperfusion (I/R). The TLR family of receptors involved in alerting the innate immune system of danger seems to be activated by damage-associated molecular pattern molecules (DAMPs) that are released during conditions of oxidative stress. In this review, we examine the role of TLRs in various experimental models of oxidative stress such as HS and I/R. We also report on potential DAMPs that may interact with TLRs in mediating injury. Finally, potential mechanisms by which reactive oxygen species from NADPH oxidase can signal the commencement of inflammatory pathways through TLRs are explored. (c) 2009 Elsevier Inc. All rights reserved.
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          Chronic Inflammation and Oxidative Stress as a Major Cause of Age- Related Diseases and Cancer

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            Author and article information

            Journal
            Toxicological Sciences
            Toxicol. Sci.
            Oxford University Press (OUP)
            1096-6080
            1096-0929
            December 05 2016
            December 07 2016
            : 154
            : 2
            : 341-353
            10.1093/toxsci/kfw170
            © 2016

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