Electrophysiologic substrate in congenital Long QT syndrome: noninvasive mapping with electrocardiographic imaging (ECGI).

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Abstract

Congenital Long QT syndrome (LQTS) is an arrhythmogenic disorder that causes syncope and sudden death. Although its genetic basis has become well-understood, the mechanisms whereby mutations translate to arrhythmia susceptibility in the in situ human heart have not been fully defined. We used noninvasive ECG imaging to map the cardiac electrophysiological substrate and examine whether LQTS patients display regional heterogeneities in repolarization, a substrate that promotes arrhythmogenesis.

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Journal ID (iso-abbrev): Circulation

Title: Circulation

ISSN (Electronic): 1524-4539

ISSN (Print): 0009-7322

Publication date (Electronic): Nov 25 2014

Volume: 130

Issue: 22

Affiliations

[1 ] From the Cardiac Bioelectricity and Arrhythmia Center (R.V., J.N.A.S., G.F.V.H., Y.R.) and Department of Biomedical Engineering (R.V., Y.R.), Washington University in St. Louis, Saint Louis, MO; Division of Pediatric Cardiology, Washington University School of Medicine/St. Louis Children's Hospital, St. Louis, MO (J.N.A.S., G.F.V.H., Y.R.); Cardiovascular Diseases, Mount Sinai St. Luke's Roosevelt, Icahn School of Medicine at Mount Sinai, New York, NY (K.A.D.); Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN (R.L.A., D.M.R.); CardioInsight Technologies, Cleveland, OH (M.S.); Bordeaux University Hospital, LIRYC institute, Pessac, France (F.S., M.H.); and the Department of Medicine (Cardiology), Washington University School of Medicine/Barnes-Jewish Hospital, St. Louis, MO (Y.R.).

[2 ] From the Cardiac Bioelectricity and Arrhythmia Center (R.V., J.N.A.S., G.F.V.H., Y.R.) and Department of Biomedical Engineering (R.V., Y.R.), Washington University in St. Louis, Saint Louis, MO; Division of Pediatric Cardiology, Washington University School of Medicine/St. Louis Children's Hospital, St. Louis, MO (J.N.A.S., G.F.V.H., Y.R.); Cardiovascular Diseases, Mount Sinai St. Luke's Roosevelt, Icahn School of Medicine at Mount Sinai, New York, NY (K.A.D.); Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN (R.L.A., D.M.R.); CardioInsight Technologies, Cleveland, OH (M.S.); Bordeaux University Hospital, LIRYC institute, Pessac, France (F.S., M.H.); and the Department of Medicine (Cardiology), Washington University School of Medicine/Barnes-Jewish Hospital, St. Louis, MO (Y.R.). rudy@wustl.edu.

Article

Publisher Item ID: CIRCULATIONAHA.114.011359 Mid ID: NIHMS630720

DOI: 10.1161/CIRCULATIONAHA.114.011359

PubMed ID: 25294783

SO-VID: 76860f35-33bf-46f7-befd-c423d6dadf74

History

Keywords: ECG imaging,arrhythmia,electrophysiology,imaging, diagnostic,long-QT syndrome

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Keywords: ECG imaging, arrhythmia, electrophysiology, imaging, diagnostic, long-QT syndrome

Electrophysiologic substrate in congenital Long QT syndrome: noninvasive mapping with electrocardiographic imaging (ECGI).

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