Concentration of salicylate in serum and perilymph of the chinchilla.

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Abstract

The concentration of salicylate in serum and perilymph was measured in chinchillas after intraperitoneal administration of sodium salicylate. Serum salicylate concentration peaked 2 to 4 hours after a single injection. Clearance was approximately complete after 16 hours. The within-subject variability of serum concentration 4 hours after injection was very low. Subject weight significantly affected serum salicylate concentration, with heavier animals showing higher serum levels. The relationship of perilymph to serum salicylate concentration was approximately linear, with a high correlation between measures.

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Journal

Journal ID (iso-abbrev): Arch. Otolaryngol. Head Neck Surg.

Title: Archives of otolaryngology--head & neck surgery

ISSN: 0886-4470

ISSN (Print): 0886-4470

Publication date (Electronic): Jun 1990

Volume: 116

Issue: 6

Affiliations

[1 ] Department of Communicative Disorders and Sciences, State University of New York, Buffalo 14214.

Article

PubMed ID: 2340120

SO-VID: 768a9a67-20e0-4abf-9532-6c9b8d23c2c4

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