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      Serum Insulin-Like Growth Factors I and II Are Not Affected by Undernutrition in Children with Nonorganic Failure to Thrive

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          The aim of our study was to determine the serum levels of IGF-I, IGF-II, and their binding proteins IGFBP-1 and IGFBP-3 in young children 3 months to 2 years of age with nonorganic failure to thrive (NOFTT). 29 children with NOFTT and 32 normal controls were recruited and studied for auxologic and hormonal parameters. The NOFTT group had significantly higher serum concentrations of IGFBP-1 than the control group: 57.7 ± 18 vs. 48 ± 19 µg/l (p < 0.05). IGF-I and IGF-II serum levels were highly correlated to serum IGFBP-3 but there were no differences in the serum IGF-I, IGF-II and IGFBP-3 levels between the groups. We conclude that IGF-I, IGF-II, and IGFBP-3 are not useful for the evaluation of nutritional status in children, under the age of 2 years, with NOFTT.

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          Most cited references 2

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          Nutritional regulation of the insulin-like growth factors

           J. Thissen (1994)
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            Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation

             A Juul (1995)

              Author and article information

              Horm Res Paediatr
              Hormone Research in Paediatrics
              S. Karger AG
              February 1998
              14 January 1998
              : 49
              : 2
              : 76-79
              a Pediatric Diagnostic and Therapeutic Center, and b S. Daniel Abraham International Center for Health and Nutrition, Soroka Medical Center and Ben Gurion University of the Negev, Beer-Sheva, Israel
              23130 Horm Res1998;49:76–79
              © 1998 S. Karger AG, Basel

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              Tables: 1, References: 17, Pages: 4
              Original Paper


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