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      Discovery of 3-Benzyl-1-(trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors

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          Journal
          Journal of Medicinal Chemistry
          J. Med. Chem.
          American Chemical Society (ACS)
          0022-2623
          1520-4804
          August 20 2018
          August 20 2018
          Affiliations
          [1 ]Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan
          [2 ]Department of Structural Biology, Takeda California Inc., 10410 Science Center Drive, San Diego, California 92121, United States
          [3 ]Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
          [4 ]Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada
          [5 ]Department of Molecular Oncology, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
          Article
          10.1021/acs.jmedchem.8b00683
          © 2018
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