12
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Monoclonal antibody specific for IDH1 R132H mutation.

      Acta Neuropathologica
      Animals, Antibodies, Monoclonal, immunology, metabolism, Arginine, genetics, Astrocytoma, Brain Neoplasms, Histidine, Humans, Isocitrate Dehydrogenase, Mice, Mutant Proteins, Mutation, Oligodendroglioma, Sensitivity and Specificity

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          IDH1 R132H mutations occur in approximately 70% of astrocytomas and oligodendroglial tumors. We developed a mouse monoclonal antibody targeting the IDH1 R132H mutation. Here, we show the high specificity and sensitivity of this antibody on Western blots and tissue sections from formalin fixed paraffin embedded tumor specimens. This antibody is highly useful for tumor classification, in detecting single infiltrating tumor cells and for the characterization of the cellular role of mutant IDH1 protein.

          Related collections

          Author and article information

          Comments

          Comment on this article