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      Effect of Adrenalectomy on a Diurnal (Circadian) Rhythm in Hypothalamic Multiple Unit Activity in the Female Rat

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          Abstract

          In freely-moving female rats multiple unit activity(MUA) was recorded from medial hypothalamic and septal structures for 4–7 days throughout the estrous cycle. A consistent elevation of MUA during paradoxical sleep (PS) was superimposed on a clearcut circadian rhythm with maximal acti-vity during the night and minimal activity during the day. The circadian rhythm of MUA did not show variations related to the phases of the 4-day estrous cycle and was not altered either by ovariectomy or by administration of exogenous estrogen. In contrast, the diurnal cycle of MUA was completely abolished within 3 weeks following adrenalectomy. It is suggested that the circadian rhythm of hypothalamic MUA in the female rat may be related to the rhythm of secretion of ACTH and/or hypothalamic corticotropin-releasing-factor (CRF).

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1974
          1974
          20 March 2008
          : 14
          : 2
          : 103-113
          Affiliations
          Department of Anatomy and Brain Research Institute, UCLA School of Medicine, Los Angeles, Calif.
          Article
          122250 Neuroendocrinology 1974;14:103–113
          10.1159/000122250
          4362526
          © 1974 S. Karger AG, Basel

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          Page count
          Pages: 11
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