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      Comparative Biochemistry and In Vitro Pathway Reconstruction as Powerful Partners in Studies of Metabolic Diversity.

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          Abstract

          There are estimated to be >300,000 plant species, producing >200,000 metabolites. Many of these metabolites are restricted to specific plant lineages and are referred to as "specialized" metabolites. These serve varied functions in plants including defense against biotic and abiotic stresses, plant-plant and plant-microbe communication, and pollinator attraction. These compounds also have important applications in agriculture, medicine, skin care, and in diverse aspects of human culture. The specialized metabolic repertoire of plants can vary even within and between closely related species, in terms of the number and classes of specialized metabolites as well as their structural variants. This phenotypic variation can be exploited to discover the underlying variation in the metabolic enzymes. We describe approaches for using the diversity of specialized metabolites and variation in enzyme structure and function to identify novel enzymatic activities and understand the structural basis for these differences. The knowledge obtained from these studies will provide new modules for the synthetic biology toolbox.

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          Author and article information

          Journal
          Meth. Enzymol.
          Methods in enzymology
          Elsevier BV
          1557-7988
          0076-6879
          2016
          : 576
          Affiliations
          [1 ] Michigan State University, East Lansing, MI, United States.
          [2 ] Michigan State University, East Lansing, MI, United States. Electronic address: lastr@msu.edu.
          Article
          S0076-6879(16)00107-5
          10.1016/bs.mie.2016.02.023
          27480680

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