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      Synthesis of a novel Cu/DPA-MOF/OP/CS hydrogel with high capability in antimicrobial studies

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          Abstract

          Today, with the indiscriminate use of antibiotics, we face the resistance of some bacterial strains against some antibiotics. Therefore, it is essential to report and synthesize new compounds with antimicrobial properties. A novel copper/dipicolinic acid–metal–organic framework cross-linked oxidized pectin and chitosan (Cu/DPA-MOF/OP/CS) hydrogel polymer was synthesized under environmental conditions with the controllable process, which uses biodegradable polymer compounds such as pectin and chitosan in its structure. The efficient physicochemical features of the synthesized Cu/DPA-MOF/OP/CS hydrogel using SEM, FT-IR, TGA, BET, XRD, and EDS/mapping were identified and confirmed. The newly synthesized Cu/DPA-MOF/OP/CS hydrogel showed activity against Gram-positive and Gram-negative bacterial strains and fungal species, and significant antibacterial and antifungal properties were observed. In antibacterial activity, the MIC against Gram-positive species was in the range of 16–128 mg/mL, the MIC against Gram-negative species was in the range of 64–256 mg/mL, and the MIC against fungal species was in the range of 128–512 mg/mL. In antimicrobial evaluations, in addition to the MIC test, the MBC test, the MFC test, and the IZD test were performed, and the results were reported. The results were compared with commercial antibiotics in the market. Development of novel nanostructures based on hydrogel polymers with distinctive functionality can affect the performance of these nanostructures in different areas.

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          Most cited references43

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          A Review on Production of Metal Organic Frameworks (MOF) for CO2 Adsorption

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            Review on the Antimicrobial Properties of Carbon Nanostructures

            Swift developments in nanotechnology have prominently encouraged innovative discoveries across many fields. Carbon-based nanomaterials have emerged as promising platforms for a broad range of applications due to their unique mechanical, electronic, and biological properties. Carbon nanostructures (CNSs) such as fullerene, carbon nanotubes (CNTs), graphene and diamond-like carbon (DLC) have been demonstrated to have potent broad-spectrum antibacterial activities toward pathogens. In order to ensure the safe and effective integration of these structures as antibacterial agents into biomaterials, the specific mechanisms that govern the antibacterial activity of CNSs need to be understood, yet it is challenging to decouple individual and synergistic contributions of physical, chemical and electrical effects of CNSs on cells. In this article, recent progress in this area is reviewed, with a focus on the interaction between different families of carbon nanostructures and microorganisms to evaluate their bactericidal performance.
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              Metal–Organic-Framework-Based Materials for Antimicrobial Applications

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                Author and article information

                Contributors
                Journal
                Front Chem
                Front Chem
                Front. Chem.
                Frontiers in Chemistry
                Frontiers Media S.A.
                2296-2646
                11 August 2023
                2023
                : 11
                : 1236580
                Affiliations
                [1] 1 College of Dentistry , Al-Mustaqbal University , Babylon, Iraq
                [2] 2 College of Technical Engineering , Imam Ja’afar Al-Sadiq University , Al-Muthanna, Iraq
                [3] 3 Department of Medical Laboratories Technology , Al-Nisour University College , Al-Mansour, Iraq
                [4] 4 College of Pharmacy , Al-Ayen University , Nasiriyah, Thi-Qar, Iraq
                [5] 5 Department of Medical Engineering , Al-Esraa University College , Baghdad, Iraq
                [6] 6 College of Health and Medical Technology , National University of Science and Technology , Nasiriyah, Thi-Qar, Iraq
                [7] 7 Department of Clinical Laboratory Sciences , College of Applied Medical Sciences , King Khalid University , Abha, Saudi Arabia
                [8] 8 Technical Engineering Department College of Technical Engineering , The Islamic University , Najaf, Iraq
                [9] 9 Department of Physics , College of Science , University of Kufa , Kufa, Iraq
                [10] 10 Medical Technical College , College of Pharmacy , University of Al-Ameed , Karbala, Iraq
                Author notes

                Edited by: Michelina Soccio, University of Bologna, Italy

                Reviewed by: Hossein Molavi, Sharif University of Technology, Iran

                Somayeh Sadighian, Zanjan University of Medical Sciences, Iran

                *Correspondence: Ali Alsalamy, alihashimalsalamy78@ 123456gmail.com
                Article
                1236580
                10.3389/fchem.2023.1236580
                10450620
                76b2045b-b073-44fb-9f67-fcd68cd388a3
                Copyright © 2023 Jasim Al-Khafaji, Alsalamy, Abed Jawad, Ali Nasser, Dawood, Hasan, Ahmad, Gatea and Younis Albahadly.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 07 June 2023
                : 31 July 2023
                Categories
                Chemistry
                Original Research
                Custom metadata
                Polymer Chemistry

                hydrogel,oxidized pectin,chitosan,copper metal–organic framework,antimicrobial study

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