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      COX2 inhibition reduces aortic valve calcification in vivo.

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          Abstract

          Calcific aortic valve disease (CAVD) is a significant cause of morbidity and mortality, which affects ≈1% of the US population and is characterized by calcific nodule formation and stenosis of the valve. Klotho-deficient mice were used to study the molecular mechanisms of CAVD as they develop robust aortic valve (AoV) calcification. Through microarray analysis of AoV tissues from klotho-deficient and wild-type mice, increased expression of the gene encoding cyclooxygenase 2 (COX2; Ptgs2) was found. COX2 activity contributes to bone differentiation and homeostasis, thus the contribution of COX2 activity to AoV calcification was assessed.

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          Author and article information

          Journal
          Arterioscler. Thromb. Vasc. Biol.
          Arteriosclerosis, thrombosis, and vascular biology
          Ovid Technologies (Wolters Kluwer Health)
          1524-4636
          1079-5642
          Apr 2015
          : 35
          : 4
          Affiliations
          [1 ] From The Heart Institute, Cincinnati Children's Hospital Medical Center, OH.
          [2 ] From The Heart Institute, Cincinnati Children's Hospital Medical Center, OH. Katherine.Yutzey@cchmc.org.
          Article
          ATVBAHA.114.305159 NIHMS808054
          10.1161/ATVBAHA.114.305159
          4979542
          25722432

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