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      Helicobacter pylori virulence and genetic geography.

      Science (New York, N.Y.)

      transmission, Animals, Bacterial Vaccines, Biological Evolution, Child, Genetic Variation, Helicobacter Infections, epidemiology, microbiology, prevention & control, Adult, Helicobacter pylori, genetics, immunology, pathogenicity, Humans, Peptic Ulcer, Stomach, Stomach Neoplasms, Virulence

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          Abstract

          Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori.

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          10334982

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