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      Software for constructing and verifying pedigrees within large genealogies and an application to the Old Order Amish of Lancaster County.

      Genome research
      Christianity, Computer Graphics, Databases, Factual, Female, Genetics, Medical, Genetics, Population, Humans, Inbreeding, Information Storage and Retrieval, Male, Pedigree, Pennsylvania, ethnology, Software

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          Abstract

          This paper describes PedHunter, a software package that facilitates creation and verification of pedigrees within large genealogies. A frequent problem in medical genetics is to connect distant relatives with a pedigree. PedHunter uses methods from graph theory to solve two versions of the pedigree connection problem for genealogies as well as other pedigree analysis problems. The pedigrees are produced by PedHunter as files in LINKAGE format ready for linkage analysis. PedHunter uses a relational database of genealogy data, with tables in specified format, for all calculations. The functionality and utility of PedHunter are illustrated by examples using the Amish Genealogy Database (AGDB), which was created for the Old Order Amish community of Lancaster County, Pennsylvania.

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          Programs for Pedigree Analysis: MENDEL, FISHER, and dGENE.

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            The SWISS-PROT protein sequence data bank and its supplement TrEMBL.

            SWISS-PROT is a curated protein sequence database which strives to provide a high level of annotations (such as the description of the function of a protein, structure of its domains, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other databases. Recent developments of the database include: an increase in the number and scope of model organisms; cross-references to two additional databases; a variety of new documentation files and the creation of TrEMBL, a computer annotated supplement to SWISS-PROT. This supplement consists of entries in SWISS-PROT-like format derived from the translation of all coding sequences (CDS) in the EMBL nucleotide sequence database, except the CDS already included in SWISS-PROT.
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              Steiner tree problems

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