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      Ginseng polysaccharide serves as a potential radiosensitizer through inducing apoptosis and autophagy in the treatment of osteosarcoma.

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          Abstract

          Recent studies have confirmed that the combined use of anti-cancer drugs with ionizing radiation (IR) could improve the sensitivity of osteosarcoma (OS) cells. Therefore, it is necessary to identify potential effective drugs for the enhancement of IR-radiosensitivity. In the current study, we found that 20, 10, 5, and 1 μM of ginseng polysaccharide (GPS) significantly suppressed MG-63 cell viability with or without γ-ray radiation in a dose- and time-dependent manner. Strikingly, 20 μM of GPS combined with 5 Gy treatment suppressed colony formation capacity by nearly 13.75∼fold compared with IR treatment alone. Our results showed that GPS could markedly induce early apoptosis and autophagy in MG-63 cells. A higher drug concentration and a greater exposure dose were directly associated with more apoptosis and autophagy in cells. Western blot analysis showed that GPS decreased the phosphorylation of p38 and AKT as well as the protein expression of Bax and cleaved-caspase3. In summary, GPS inhibited proliferation and increased apoptosis and autophagic death in OS cells, indicating that GPS may be a potential effective auxiliary drug for improving the IR sensitivity of OS patients.

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          Author and article information

          Journal
          Kaohsiung J. Med. Sci.
          The Kaohsiung journal of medical sciences
          Elsevier BV
          1607-551X
          1607-551X
          Nov 2017
          : 33
          : 11
          Affiliations
          [1 ] Department of Orthopedics, Ningxia People's Hospital, Ningxia Province, China.
          [2 ] Department of Orthopedics, Shangluo Central Hospital, Shangluo City, Shaanxi Province, China.
          [3 ] Department of Hand surgery, Ruian Municipal People's Hospital, Ruian City, Zhejiang Province, China.
          [4 ] Department of Orthopedic Surgery, Hong Hui Hospital Xi'an Jiaotong University, Xi'an City, Shaanxi Province, China.
          [5 ] Department of Orthopedic Surgery, Hong Hui Hospital Xi'an Jiaotong University, Xi'an City, Shaanxi Province, China. Electronic address: yuyonghua126@163.com.
          Article
          S1607-551X(17)30272-3
          10.1016/j.kjms.2017.07.001
          29050670

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