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      Large Artery Stiffness: A Companion to the 2015 AHA Science Statement on Arterial Stiffness

      a , b , c
      S. Karger AG
      Arterial stiffness, Guideline, Pulse wave velocity

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          Large artery stiffness (LAS) has proven to be an independent risk factor for cardiovascular disease and mortality. Nevertheless, the position of current hypertension guidelines regarding the usefulness of assessing LAS differs across different continents. In general, European Guidelines recognize pulse wave velocity (PWV) as a marker of target organ damage but do not recommend its systematic use in general population. Asian guidelines consider PWV as a recommended test at diagnosis of hypertension, in contrast to North American guidelines that do not state any position about its usefulness. However, PWV predicts cardiovascular events, and several studies have shown that it improves risk classification adjusting for established risk factors especially for intermediate-risk patients. Finally, some advances have been made related to treatments affecting LAS. Dietary interventions such as sodium restriction and exercise-based interventions have a modest effect in reducing LAS. Pharmacological interventions, such as statins, or more recent advances with mineralocorticoid blocker seem to have a beneficial effect. Last, controversial effects of renal denervation on LAS have been found. Our goal here is to update the reader on LAS on these areas since the 2015 American Heart Association Scientific Statement.

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          Most cited references52

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          2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts)Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR).

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            2020 International Society of Hypertension Global Hypertension Practice Guidelines

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              The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)


                Author and article information

                S. Karger AG
                September 2021
                19 August 2021
                : 9
                : 1-2
                : 1-10
                [_a] aDepartment of Preventive Medicine and Public Health, Universidad Autónoma de Madrid, Madrid, Spain
                [_b] bInternal Medicine Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain
                [_c] cPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
                Author information
                518613 Pulse 2021;9:1–10
                © 2021 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                : 29 March 2021
                : 15 July 2021
                Page count
                Figures: 1, Tables: 3, Pages: 10
                Review Article

                General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
                Arterial stiffness,Pulse wave velocity,Guideline


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