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      Retracted: α-Cyperone Protects Cardiomyocytes against Oxygen-Glucose Deprivation-Induced Inflammation and Oxidative Stress by Akt/FOXO3a/NF- κB Pathway

      retraction
      Disease Markers
      Hindawi

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          Abstract

          This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation The presence of these indicators undermines our confidence in the integrity of the article's content and we cannot, therefore, vouch for its reliability. Please note that this notice is intended solely to alert readers that the content of this article is unreliable. We have not investigated whether authors were aware of or involved in the systematic manipulation of the publication process. Wiley and Hindawi regrets that the usual quality checks did not identify these issues before publication and have since put additional measures in place to safeguard research integrity. We wish to credit our own Research Integrity and Research Publishing teams and anonymous and named external researchers and research integrity experts for contributing to this investigation. The corresponding author, as the representative of all authors, has been given the opportunity to register their agreement or disagreement to this retraction. We have kept a record of any response received.

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          α-Cyperone Protects Cardiomyocytes against Oxygen-Glucose Deprivation-Induced Inflammation and Oxidative Stress by Akt/FOXO3a/NF- κB Pathway

          Objective This study is aimed at investigating the mechanism of α -cyperone in oxygen and glucose deprivation- (OGD-) induced myocardial injury. Methods Cardiomyocytes were exposed to OGD and then treated with α -cyperone. The cell counting kit-8 (CCK-8) assay and flow cytometry were performed to determine cell proliferation and apoptosis, respectively. The expression of inflammatory factors was monitored by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The profiles of apoptosis-related proteins, inflammatory proteins, and the Akt/FOXO3a/NF- κ B pathway were determined by western blot. The phosphorylation of Akt, FOXO3a, and NF- κ B was determined by immunofluorescence assay. The superoxide dismutase (SOD) activity and the malondialdehyde (MDA) content were gauged by the colorimetric method, and the reactive oxygen species (ROS) content was measured. Results α -Cyperone hindered OGD-induced inflammation, oxidative stress, and apoptosis in cardiomyocytes. OGD activated the FOXO3a/NF- κ B pathway and hampered the Akt phosphorylation. α -cyperone reversed OGD-mediated FOXO3a/NF- κ B pathway activation. Treatment with MK-2206 abated the protective effect of α -cyperone against OGD-induced myocardial injury. The addition of α -cyperone to cardiomyocytes following Bay11-7082 treatment had no conspicuous effect on the viability and apoptosis. Conclusions α -Cyperone protected cardiomyocytes against OGD-induced inflammation and oxidative stress via the Akt/FOXO3a/NF- κ B axis.
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            Author and article information

            Contributors
            Journal
            Dis Markers
            Dis Markers
            DM
            Disease Markers
            Hindawi
            0278-0240
            1875-8630
            2023
            19 July 2023
            19 July 2023
            : 2023
            : 9814542
            Affiliations
            Article
            10.1155/2023/9814542
            10371448
            76f77a43-7a21-4ce3-96cf-f1cd4e1dd24a
            Copyright © 2023 Disease Markers.

            This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

            History
            : 18 July 2023
            : 18 July 2023
            Categories
            Retraction

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