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      Effect of diet-induced obesity or type 1 or type 2 diabetes on corneal nerves and peripheral neuropathy in C57Bl/6J mice.

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          Abstract

          We determined the impact diet-induced obesity (DIO) and types 1 and 2 diabetes have on peripheral neuropathy with emphasis on corneal nerve structural changes in C57Bl/6J mice. Endpoints examined included nerve conduction velocity, response to thermal and mechanical stimuli and innervation of the skin and cornea. DIO mice and to a greater extent type 2 diabetic mice were insulin resistant. DIO and both types 1 and 2 diabetic mice developed motor and sensory nerve conduction deficits. In the cornea of DIO and type 2 diabetic mice there was a decrease in sub-epithelial corneal nerves, innervation of the corneal epithelium, and corneal sensitivity. Type 1 diabetic mice did not present with any significant changes in corneal nerve structure until after 20 weeks of hyperglycemia. DIO and type 2 diabetic mice developed corneal structural damage more rapidly than type 1 diabetic mice although hemoglobin A1 C values were significantly higher in type 1 diabetic mice. This suggests that DIO with or without hyperglycemia contributes to development and progression of peripheral neuropathy and nerve structural damage in the cornea.

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          Author and article information

          Journal
          J. Peripher. Nerv. Syst.
          Journal of the peripheral nervous system : JPNS
          Wiley-Blackwell
          1529-8027
          1085-9489
          Mar 2015
          : 20
          : 1
          Affiliations
          [1 ] Department of Veterans Affairs Iowa City Health Care System, Iowa City, IA, USA.
          [2 ] Veterans Affairs Center for the Prevention and Treatment of Visual Loss, Iowa City, IA, USA.
          [3 ] Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
          [4 ] Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA.
          [5 ] Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA.
          Article
          NIHMS694830
          10.1111/jns.12111
          4470853
          25858759

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