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      Behavioral characterization of pentylenetetrazol-induced seizures in the marmoset.

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          Abstract

          This study was designed to characterize seizures induced with pentylenetetrazol (PTZ) in marmosets. Thirteen adult marmosets (Callithrix sp.) received 20, 30, or 40 mg/kg of PTZ intraperitoneally. PTZ caused all animals to switch their natural behavioral repertoire to early convulsive behavior. Seizure scores were low at lower PTZ doses, whereas the highest dose of PTZ led to seizure scores IV and V (according to Racine's scale) in 69% of animals. To further characterize the model we performed a preliminary evaluation of the efficacy of three antiepileptic drugs: phenobarbital, phenytoin, and carbamazepine. Phenobarbital prevented PTZ-induced seizures in 100% of trials. As expected, phenytoin and carbamazepine were not effective against PTZ-induced seizures. The present study describes the PTZ model of seizures in marmosets with a drug-response profile similar to that of the rodent model, thus bringing to a well-known model (PTZ in rodents) the complexity of a nonhuman primate brain.

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          Author and article information

          Journal
          Epilepsy Behav
          Epilepsy & behavior : E&B
          Elsevier BV
          1525-5069
          1525-5050
          Jul 2008
          : 13
          : 1
          Affiliations
          [1 ] Department of Physiology, Universidade Federal de São Paulo, Sao Paulo, Brazil.
          Article
          S1525-5050(08)00024-3
          10.1016/j.yebeh.2008.02.010
          18337181
          77156b63-8d61-4925-8a30-2ba0cc1ffc5c
          History

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