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      Susceptibility pattern and molecular type of species-specific Candida in oropharyngeal lesions of Indian human immunodeficiency virus-positive patients.

      Journal of Clinical Microbiology
      AIDS-Related Opportunistic Infections, microbiology, CD4 Lymphocyte Count, Candida, drug effects, isolation & purification, Candidiasis, Oral, diagnosis, immunology, DNA Fingerprinting, DNA, Fungal, genetics, Drug Resistance, Fungal, Fluconazole, pharmacology, HIV Seropositivity, Humans, Microbial Sensitivity Tests

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          Abstract

          A study of oropharyngeal candidiasis (OPC) in Indian human immunodeficiency virus (HIV)/AIDS patients was conducted over a period of 15 months. This study revealed that 75% of the HIV/AIDS patients had OPC. MIC testing revealed that 5% of the Candida isolates were fluconazole resistant. A correlation between CD4(+)-T-cell counts and development of OPC in HIV/AIDS patients was also observed. Molecular typing of C. albicans isolates showed that all were genetically unrelated.

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