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      Polyphonic sonification of electrocardiography signals for diagnosis of cardiac pathologies

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          Abstract

          Electrocardiography (ECG) data are multidimensional temporal data with ubiquitous applications in the clinic. Conventionally, these data are presented visually. It is presently unclear to what degree data sonification (auditory display), can enable the detection of clinically relevant cardiac pathologies in ECG data. In this study, we introduce a method for polyphonic sonification of ECG data, whereby different ECG channels are simultaneously represented by sound of different pitch. We retrospectively applied this method to 12 samples from a publicly available ECG database. We and colleagues from our professional environment then analyzed these data in a blinded way. Based on these analyses, we found that the sonification technique can be intuitively understood after a short training session. On average, the correct classification rate for observers trained in cardiology was 78%, compared to 68% and 50% for observers not trained in cardiology or not trained in medicine at all, respectively. These values compare to an expected random guessing performance of 25%. Strikingly, 27% of all observers had a classification accuracy over 90%, indicating that sonification can be very successfully used by talented individuals. These findings can serve as a baseline for potential clinical applications of ECG sonification.

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          Most cited references12

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          Visualization of image data from cells to organisms.

          Advances in imaging techniques and high-throughput technologies are providing scientists with unprecedented possibilities to visualize internal structures of cells, organs and organisms and to collect systematic image data characterizing genes and proteins on a large scale. To make the best use of these increasingly complex and large image data resources, the scientific community must be provided with methods to query, analyze and crosslink these resources to give an intuitive visual representation of the data. This review gives an overview of existing methods and tools for this purpose and highlights some of their limitations and challenges.
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            Visualizing biological data-now and in the future.

            Methods and tools for visualizing biological data have improved considerably over the last decades, but they are still inadequate for some high-throughput data sets. For most users, a key challenge is to benefit from the deluge of data without being overwhelmed by it. This challenge is still largely unfulfilled and will require the development of truly integrated and highly useable tools.
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              Event-based sonification of EEG rhythms in real time.

              To introduce a sound synthesis tool for human EEG rhythms that is applicable in real time. We design an event-based sonification which suppresses irregular background and highlights normal and pathologic rhythmic activity. We generated sound examples with rhythms from well-known epileptic disorders and find stereotyped rhythmic auditory objects in single channel and stereo display from generalized spike-wave runs. For interictal activity, we were able to separate focal rhythms from background activity and thus enable the listener to perceive its frequency, duration, and intensity while monitoring. The proposed event-based sonification allows quick detection and identification of different types of rhythmic EEE events in real time and can thus be used to complement visual displays in monitoring and EEG feedback tasks. The significance of the work lies in the fact that it can be implemented for on-line monitoring of clinical EEG and for EEG feedback applications where continuous screen watching can be substituted or improved by the auditory information stream.
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                Author and article information

                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group
                2045-2322
                20 March 2017
                2017
                : 7
                : 44549
                Affiliations
                [1 ]Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University , Mannheim, Germany
                [2 ]Department of Medical Oncology and Internal Medicine VI, National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg University , Heidelberg, Germany
                [3 ]Ambient Intelligence Group, Center of Excellence in Cognitive Interaction Technology (CITEC), Bielefeld University , Bielefeld, Germany
                [4 ]Klinik III für Innere Medizin, Herzzentrum der Universität zu Köln , Cologne, Germany
                Author notes
                Article
                srep44549
                10.1038/srep44549
                5357951
                28317848
                771f23d5-7922-4e2e-ba32-fd63d65fefeb
                Copyright © 2017, The Author(s)

                This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

                History
                : 01 November 2016
                : 10 February 2017
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