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      • Record: found
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      • Article: found

      Treatment of Blood Hyperviscosity with Calcium Dobesilate in Patients with Diabetic Retinopathy

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          Abstract

          This double-blind randomized trial was carried out on 37 patients with diabetic retinopathy and blood hyperviscosity. 19 patients received calcium dobesilate in capsules of 500 mg 3 times daily for 3 months and 18 patients took 3 placebo capsules daily during the same period. Calcium dobesilate was found to reduce whole-blood viscosity in a statistically significant manner which was accompanied by a diminution of the albumin/globulin ratio and a significant reduction of fibrinogen and cholesterol levels. A statistically significant diminution of capillary fragility was also observed in the calcium dobesilate-treated group. These results indicate that calcium dobesilate, by restoring the integrity of the microvessels, and by lowering blood viscosity, could act favorably on the evolution of diabetic retinopathy.

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1985
          Publication date (Print): 1985
          Publication date (Electronic): 04 December 2009
          Volume: 17
          Issue: 3
          Pages: 131-138
          Affiliations
          aDepartment of Diabetology, and bDepartment of Ophthalmology, Jewish Hospital; cCastex’s Hospital; dDepartment of Obstetrics, University of Buenos Aires; eDepartment of Obstetrics, Juan Santojanni General Hospital, Buenos Aires, Argentina
          Article
          Publisher ID: 265364 Other ID: Ophthalmic Res 1985;17:131–138
          DOI: 10.1159/000265364
          PubMed ID: 4011126
          SO-VID: 7739466e-5f53-4505-b65c-aa7bacb1d787
          Copyright © © 1985 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 24 May 1984
          Date accepted : 23 July 1984
          Page count
          Pages: 8
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Plasma fibrinogen,Diabetic retinopathy,Capillary fragility,Calcium dobesilate,Cholesterol,Albumin/globulin-ratio,Blood viscosity
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Plasma fibrinogen, Diabetic retinopathy, Capillary fragility, Calcium dobesilate, Cholesterol, Albumin/globulin-ratio, Blood viscosity

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