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      Treatment of Blood Hyperviscosity with Calcium Dobesilate in Patients with Diabetic Retinopathy

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          This double-blind randomized trial was carried out on 37 patients with diabetic retinopathy and blood hyperviscosity. 19 patients received calcium dobesilate in capsules of 500 mg 3 times daily for 3 months and 18 patients took 3 placebo capsules daily during the same period. Calcium dobesilate was found to reduce whole-blood viscosity in a statistically significant manner which was accompanied by a diminution of the albumin/globulin ratio and a significant reduction of fibrinogen and cholesterol levels. A statistically significant diminution of capillary fragility was also observed in the calcium dobesilate-treated group. These results indicate that calcium dobesilate, by restoring the integrity of the microvessels, and by lowering blood viscosity, could act favorably on the evolution of diabetic retinopathy.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          04 December 2009
          : 17
          : 3
          : 131-138
          aDepartment of Diabetology, and bDepartment of Ophthalmology, Jewish Hospital; cCastex’s Hospital; dDepartment of Obstetrics, University of Buenos Aires; eDepartment of Obstetrics, Juan Santojanni General Hospital, Buenos Aires, Argentina
          265364 Ophthalmic Res 1985;17:131–138
          © 1985 S. Karger AG, Basel

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          Pages: 8
          Original Paper


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