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      Plasmapheresis in the treatment of ataxic sensory neuropathy associated with Sjögren's syndrome.

      European neurology
      Adult, Ataxia, complications, therapy, Female, Hereditary Sensory and Motor Neuropathy, Humans, Middle Aged, Plasmapheresis, Sensation Disorders, Sjogren's Syndrome, Treatment Outcome

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          Abstract

          Sjögren's syndrome (SS) is an important but poorly recognized cause of peripheral neuropathy. Several forms of peripheral nerve dysfunction occur, including trigeminal sensory neuropathy, mononeuropathy multiplex, distal sensorimotor polyneuropathy and pure sensory neuronopathy. The pathological findings vary and the definite treatment is not known. Here we present 4 cases of acute ataxic sensory polyneuropathy with SS, and the experience of treatment with plasmapheresis (PP). The 4 patients were all females; ages ranged from 30 to 58 years. All had prominent loss of kinesthetic and proprioceptive sensation. The course ranged from acute to subacute onset. Patients were treated with 5-9 sessions of PP. Two patients with initiation of treatment within 2 weeks of onset showed dramatic and sustained responses after PP, while the other 2 had no detectable effects. Our experience showed that PP should be considered in patients who present with sensory neuropathy associated with SS, and the treatment should be given as early as possible. Copyright 2001 S. Karger AG, Basel

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